Simultaneous Determination of Methyl Nicotinate and Three Salicylic Acid Derivatives in Pain Relief Spray Using HPLC–DAD
نویسندگان
چکیده
For the first time, high-performance liquid chromatography–diode array detector (HPLC–DAD) approach was operated for simultaneous assessment of methyl nicotinate (MN), salicylate (MS), ethyl (ES) and 2-hydroxyethyl (HES) in one pharmaceutical formulation. The limits detection MN, HES, MS ES were found to be 0.0144, 0.0455, 0.0087 0.0061 μg/mL. recovery percentages relative standard deviations ranged from 93.48 102.12% 0.301 6.341% all active ingredients. Accordingly, previously described data demonstrate sensitivity, accuracy precision developed method. Therefore, investigated effectively applied DEEP HEAT Spray.
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ژورنال
عنوان ژورنال: Separations
سال: 2022
ISSN: ['2297-8739']
DOI: https://doi.org/10.3390/separations9040093